Ago3 interaction proteins in BmN4 cell
Ontology highlight
ABSTRACT:
ORGANISM(S): Bombyx Mori
SUBMITTER: Mikiko C. Siomi
PROVIDER: PXD023467 | JPOST Repository | Fri Jan 08 00:00:00 GMT 2021
REPOSITORIES: jPOST
Dataset's files
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Publications
DEAD-box polypeptide 43 facilitates piRNA amplification by actively liberating RNA from Ago3-piRISC.
Murakami Ryo R Sumiyoshi Tetsutaro T Negishi Lumi L Siomi Mikiko C MC
EMBO reports 20210208 4
The piRNA amplification pathway in Bombyx is operated by Ago3 and Siwi in their piRISC form. The DEAD-box protein, Vasa, facilitates Ago3-piRISC production by liberating cleaved RNAs from Siwi-piRISC in an ATP hydrolysis-dependent manner. However, the Vasa-like factor facilitating Siwi-piRISC production along this pathway remains unknown. Here, we identify DEAD-box polypeptide 43 (DDX43) as the Vasa-like protein functioning in Siwi-piRISC production. DDX43 belongs to the helicase superfamily II ...[more]
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