Proteomics

Dataset Information

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HLA class I ligandome of HCT15/b2m

ABSTRACT: Mass spectrometry data of the HCT15/b2m sample, which was prepared by IP using W6/32 antibody

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Takayuki Kanaseki 

PROVIDER: PXD024248 | JPOST Repository | Tue Nov 15 00:00:00 GMT 2022

REPOSITORIES: jPOST

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Publications

Characterization of Proteasome-Generated Spliced Peptides Detected by Mass Spectrometry.

Kato Koji K   Nakatsugawa Munehide M   Tokita Serina S   Hirohashi Yoshihiko Y   Kubo Terufumi T   Tsukahara Tomohide T   Murata Kenji K   Chiba Hirofumi H   Takahashi Hiroki H   Hirano Naoto N   Kanaseki Takayuki T   Torigoe Toshihiko T  

Journal of immunology (Baltimore, Md. : 1950) 20220527 12

CD8<sup>+</sup> T cells recognize peptides displayed by HLA class I molecules and monitor intracellular peptide pools. It is known that the proteasome splices two short peptide fragments. Recent studies using mass spectrometry (MS) and bioinformatics analysis have suggested that proteasome-generated spliced peptides (PSPs) may account for a substantial proportion of HLA class I ligands. However, the authenticity of the PSPs identified using bioinformatics approaches remain ambiguous. In this stu  ...[more]

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