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HLA class I ligandome of colon cancer tissues for lncRNA antigen identification

ABSTRACT: MS data of HLA class I ligandome of human colon cancer tissues

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Takayuki Kanaseki

PROVIDER: PXD024533 | JPOST Repository | Mon Sep 27 00:00:00 BST 2021

REPOSITORIES: jPOST

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CD8+ T-cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA PVT1.

Kikuchi Yasuhiro Y Tokita Serina S Hirama Tomomi T Kochin Vitaly V Nakatsugawa Munehide M Shinkawa Tomoyo T Hirohashi Yoshihiko Y Tsukahara Tomohide T Hata Fumitake F Takemasa Ichiro I Sato Noriyuki N Kanaseki Takayuki T Torigoe Toshihiko T

Cancer immunology research 20210825 11

CD8+ T cells recognize peptides displayed by HLA class I molecules on cell surfaces, monitoring pathologic conditions such as cancer. Advances in proteogenomic analysis of HLA ligandomes have demonstrated that cells present a subset of cryptic peptides derived from noncoding regions of the genome; however, the roles of cryptic HLA ligands in tumor immunity remain unknown. In the current study, we comprehensively and quantitatively investigated the HLA class I ligandome of a set of hum ...[more]

PMID: 34433589

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