Dataset Information
Mass spectrometry analysis of FLAG-5MP complexes
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
SUBMITTER: Katsura Asano
PROVIDER: PXD026284 | JPOST Repository | Thu May 27 00:00:00 BST 2021
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 1_human_1_cont_r1_AS1_L1_01.raw | Raw | |||
| 1_human_1_cont_r1_AS1_L1_02.raw | Raw | |||
| 1_human_1_cont_r1_AS1_L1_03.raw | Raw | |||
| 1_human_1_cont_r1_AS1_L1_04.raw | Raw | |||
| 1_human_1_cont_r1_AS1_L1_05.raw | Raw |
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Publications
Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
Cell reports 20210701 2
eIF5-mimic protein (5MP) is a translational regulatory protein that binds the small ribosomal subunit and modulates its activity. 5MP is proposed to reprogram non-AUG translation rates for oncogenes in cancer, but its role in controlling non-AUG initiated synthesis of deleterious repeat-peptide products, such as FMRpolyG observed in fragile-X-associated tremor ataxia syndrome (FXTAS), is unknown. Here, we show that 5MP can suppress both general and repeat-associated non-AUG (RAN) translation by ...[more]
