Proteomics

Dataset Information

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OGT-mediated AIMP2 O-GlcNAcylation promotes PARP1 overactivation in ageing-associated liver steatosis


ABSTRACT: we identified 245 down-regulated and 343 up-regulated liver proteins in aged mice. Of note, the proteins Xbp1 and Bax, which are well recognized to be involved in the regulation of ageing, were also enriched, indicating that our proteomics results are credible. Moreover,some of enriched proteins are involved in cellular processes that are widely recognized as important for aging. Livers of ageing mice exhibited changed methylation, loss of proteostasis (protein folding alteration, decreased autophagy, and increased ubiquitination), increased apoptosis, dysregulated rhythmic process, and gut dysbiosis.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Renlong Li 

PROVIDER: PXD026294 | JPOST Repository | Thu May 27 00:00:00 BST 2021

REPOSITORIES: jPOST

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