Proteomics

Dataset Information

0

Proteome analysis of affinity-purified protein co-precipitates


ABSTRACT: HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

ORGANISM(S): Homo sapiens  

SUBMITTER: Akihiko Yokoyama 

PROVIDER: PXD027400 | JPOST Repository | Tue Aug 31 00:00:00 BST 2021

REPOSITORIES: jPOST

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Publications


Leukemic oncoproteins cause uncontrolled self-renewal of hematopoietic progenitors by aberrant gene activation, eventually causing leukemia. However, the molecular mechanism underlying aberrant gene activation remains elusive. Here, we showed that leukemic MLL fusion proteins associate with the HBO1 histone acetyltransferase (HAT) complex through their trithorax homology domain 2 (THD2) in various human cell lines. MLL proteins associated with the HBO1 complex through multiple contacts mediated  ...[more]

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