Dataset Information
Proteome analysis of affinity-purified protein co-precipitates
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Akihiko Yokoyama
PROVIDER: PXD027400 | JPOST Repository | Tue Aug 31 00:00:00 GMT+01:00 2021
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| PM_HA.mzid | Mzid | |||
| PM_HA.raw | Raw | |||
| PM_HA_CID_%5BNode_07%5D.mgf | Mgf | |||
| Vector.mzid | Mzid | |||
| Vector.raw | Raw |
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Publications
HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis.
eLife 20210825
Leukemic oncoproteins cause uncontrolled self-renewal of hematopoietic progenitors by aberrant gene activation, eventually causing leukemia. However, the molecular mechanism underlying aberrant gene activation remains elusive. Here, we showed that leukemic MLL fusion proteins associate with the HBO1 histone acetyltransferase (HAT) complex through their trithorax homology domain 2 (THD2) in various human cell lines. MLL proteins associated with the HBO1 complex through multiple contacts mediated ...[more]
