Dataset Information
Proteome and peptidome analyses of mouse caecal contents and Paraprevotella clara culture supernatants
Ontology highlight
ABSTRACT:
ORGANISM(S): Paraprevotella Clara Mus Musculus (mouse)
SUBMITTER: Kenya Honda
PROVIDER: PXD027678 | JPOST Repository | Wed Jun 29 00:00:00 BST 2022
REPOSITORIES: jPOST
Publications
Identification of trypsin-degrading commensals in the large intestine.
Nature 20220907 7927
Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in intestinal pathological conditions<sup>1-3</sup>. However, the players and mechanisms that underlie protease regulation in the intestinal lumen have remained unclear. Here we show that Paraprevotella strains isolated from the faecal microbiome of healthy human donors are potent trypsin-degrading commensals. Mechanistically, Paraprevotella recruit trypsin to the bacterial surface through type IX secret ...[more]
