Dataset Information
TMT-10plex analysis of endogenous proteins expressed in HEK-293 cells as a recombinant transporter assay system
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Yoshikatsu Kanai
PROVIDER: PXD030022 | JPOST Repository | Thu Jul 07 00:00:00 BST 2022
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20190628_TMT10_HEK_mate1_F1.raw | Raw | |||
| 20190628_TMT10_HEK_mate1_F2.raw | Raw | |||
| 20190628_TMT10_HEK_mate1_F3.raw | Raw | |||
| 20190628_TMT10_HEK_mate1_F4.raw | Raw | |||
| 20190628_TMT10_HEK_mate1_F5.raw | Raw |
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Publications
Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10.
Journal of pharmacological sciences 20220617 1
OAT10 (SLC22A13) is a transporter highly expressed in renal tubules and transporting organic anions including nicotinate, β-hydroxybutyrate, p-aminohippurate, and orotate. In transport assays using Xenopus oocytes and HEK293 cells, we found that apparent substrate selectivity of OAT10 was different between the expression systems, particularly less pronounced uptake of β-hydroxybutyrate in HEK293 cells. Because functional coupling between transporters may interfere with functional properties of t ...[more]
