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BioID-based mass spectrometry data

ABSTRACT: BioID-based mass spectrometry data on stress granules

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Masaaki Oyama

PROVIDER: PXD030039 | JPOST Repository | Thu Apr 20 00:00:00 BST 2023

REPOSITORIES: jPOST

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Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases.

Fujikawa Daichi D Nakamura Takanori T Yoshioka Daisuke D Li Zizheng Z Moriizumi Hisashi H Taguchi Mari M Tokai-Nishizumi Noriko N Kozuka-Hata Hiroko H Oyama Masaaki M Takekawa Mutsuhiro M

Current biology : CB 20230428 10

Cytoplasmic stress granules (SGs) are phase-separated membrane-less organelles that form in response to various stress stimuli. SGs are mainly composed of non-canonical stalled 48S preinitiation complexes. In addition, many other proteins also accumulate into SGs, but the list is still incomplete. SG assembly suppresses apoptosis and promotes cell survival under stress. Furthermore, hyperformation of SGs is frequently observed in various human cancers and accelerates tumor development and progre ...[more]

PMID: 37119817

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