Dataset Information

MS analysis of phosphopeptides enriched from the lumbar spinal cord of SOD1G93A mice at 20weeks.

ABSTRACT: This project is "Phosphoproteomic analysis of the lumbar spinal cord, a lesion site in the amyotrophic lateral sclerosis (ALS) mouse model SOD1G93A mice". The aim of this study is to clarify the phosphorylation changes by the lumbar spinal cord of SOD1G93A mice at 20w by applying proteomics technology. The goal of this study is to better understand the pathogenesis of ALS. lumbar spinal cord of SOD1G93A mice (n=5) and WT mice (n=4) were collected at 20w, and the phosphoproteomics were compared.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Fumiaki Tanaka

PROVIDER: PXD030651 | JPOST Repository | Thu May 19 00:00:00 BST 2022

REPOSITORIES: jPOST

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Publications

Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice.

Asano Tetsuya T Nakamura Haruko H Kawamoto Yuko Y Tada Mikiko M Kimura Yayoi Y Takano Hiroshi H Yao Ryoji R Saito Hiroya H Ikeda Takuya T Komiya Hiroyasu H Kubota Shun S Hashiguchi Shunta S Takahashi Keita K Kunii Misako M Tanaka Kenichi K Goshima Yoshio Y Nakamura Fumio F Takeuchi Hideyuki H Doi Hiroshi H Tanaka Fumiaki F

eNeuro 20220523 3

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder that affects upper and lower motor neurons; however, its pathomechanism has not been fully elucidated. Using a comprehensive phosphoproteomic approach, we have identified elevated phosphorylation of Collapsin response mediator protein 1 (Crmp1) at serine 522 in the lumbar spinal cord of ALS model mice overexpressing a human superoxide dismutase mutant (SOD1<sup>G93A</sup>). We investigated the effec ...[more]

PMID: 35523582

Dataset Information

MS analysis of phosphopeptides enriched from the lumbar spinal cord of SOD1G93A mice at 20weeks.

Publications

Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice.

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