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MS-based arginine monomethylation study in Jurkat PRMT7 KO cells

ABSTRACT: Effects of Prmt7 genetic deletion to arginine monomethylation in Jurkat T-ALL cell line. Analysis was made using two different Prmt7 KO and one control cell lines.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Olli Lohi

PROVIDER: PXD032819 | JPOST Repository | Mon Mar 28 00:00:00 BST 2022

REPOSITORIES: jPOST

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Arginine Methyltransferase PRMT7 Deregulates Expression of RUNX1 Target Genes in T-Cell Acute Lymphoblastic Leukemia.

Oksa Laura L Mäkinen Artturi A Nikkilä Atte A Hyvärinen Noora N Laukkanen Saara S Rokka Anne A Haapaniemi Pekka P Seki Masafumi M Takita Junko J Kauko Otto O Heinäniemi Merja M Lohi Olli O

Cancers 20220426 9

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with no well-established prognostic biomarkers. We examined the expression of protein arginine methyltransferases across hematological malignancies and discovered high levels of <i>PRMT7</i> mRNA in T-ALL, particularly in the mature subtypes of T-ALL. The genetic deletion of <i>PRMT7</i> by CRISPR-Cas9 reduced the colony formation of T-ALL cells and changed arginine monomethylation patterns in protein complexes ...[more]

PMID: 35565298

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