Proteomics

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Prophage excision switches the primary ribosome rescue pathway and rescue-associated gene regulations in Escherichia coli

ABSTRACT: Total proteome analysis of CP4-57 prophage- and ssrA-related variants in Escherichia coli. Quantification was performed by SWATH-MS method.

ORGANISM(S): Escherichia Coli

SUBMITTER: Yuhei Chadani 

PROVIDER: PXD033190 | JPOST Repository | Wed Dec 07 00:00:00 GMT 2022

REPOSITORIES: jPOST

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Prophage excision switches the primary ribosome rescue pathway and rescue-associated gene regulations in Escherichia coli.

Onodera Haruka H   Niwa Tatsuya T   Taguchi Hideki H   Chadani Yuhei Y  

Molecular microbiology 20221205 1

Escherichia coli has multiple pathways to release nonproductive ribosome complexes stalled at the 3' end of nonstop mRNA: tmRNA (SsrA RNA)-mediated trans-translation and stop codon-independent termination by ArfA/RF2 or ArfB (YaeJ). The arfA mRNA lacks a stop codon and its expression is repressed by trans-translation. Therefore, ArfA is considered to complement the ribosome rescue activity of trans-translation, but the physiological situations in which ArfA is expressed have not been elucidated.  ...[more]