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Identification of novel biomarkers for aortic aneurysm

ABSTRACT: To discover novel biomarkers for aortic aneurysm, serum samples of patients with thoracic aortic aneurysm were fractionated, tryptic digested, and subjected to proteome analysis.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Naoto Minamino

PROVIDER: PXD033774 | JPOST Repository | Wed Nov 15 00:00:00 GMT 2023

REPOSITORIES: jPOST

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Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D.

Murakami Yusuke Y Nishigori Mitsuhiro M Yagi Hiroaki H Osaki Tsukasa T Wakabayashi Masaki M Shirai Manabu M Son Cheol C Iba Yutaka Y Minatoya Kenji K Kusano Kengo K Tomita Tsutomu T Ishibashi-Ueda Hatsue H Matsuda Hitoshi H Minamino Naoto N

Proteome science 20230805 1

<h4>Background</h4>Effective diagnostic biomarkers for aortic aneurysm (AA) that are detectable in blood tests are required because early detection and rupture risk assessment of AA can provide insights into medical therapy and preventive treatments. However, known biomarkers for AA lack specificity and reliability for clinical diagnosis.<h4>Methods</h4>We performed proteome analysis of serum samples from patients with atherosclerotic thoracic AA (TAA) and healthy control (HC) subjects to identi ...[more]

PMID: 37543598

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