Inhibition of L-type amino acid transporter 1 induces disruption of cancer amino acid homeostasis with altered cellular signals

ABSTRACT: This study characterized the changes of phosphorylation signaling cascades induced by LAT1 inhibition in three cell lines of biliary tract cancer treated with LAT1 specific inhibitor JPH203 for 15 and 30 min. Immobilized metal affinity chromatography and liquid chromatography-tandem mass spectrometry with MS2-based quantitation of tandem mass tag were utilized.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yoshikatsu Kanai 

PROVIDER: PXD034276 | JPOST Repository | Wed May 24 00:00:00 BST 2023

REPOSITORIES: jPOST