Dataset Information
Proteome analysis of muscle, liver, and blood samples associated with cancer cachexia
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
SUBMITTER: Masahiro Aoki, Yasushi Kojima
PROVIDER: PXD035832 | JPOST Repository | Fri Aug 04 00:00:00 BST 2023
REPOSITORIES: jPOST
Publications
Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia.
Nature communications 20231006 1
Cancer cachexia is a complex metabolic disorder accounting for ~20% of cancer-related deaths, yet its metabolic landscape remains unexplored. Here, we report a decrease in B vitamin-related liver enzymes as a hallmark of systemic metabolic changes occurring in cancer cachexia. Metabolomics of multiple mouse models highlights cachexia-associated reductions of niacin, vitamin B6, and a glycine-related subset of one-carbon (C1) metabolites in the liver. Integration of proteomics and metabolomics re ...[more]
