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Proteomic study of the mice treated with antibiotics

ABSTRACT: Antibiotic administration affects pharmacokinetics through changes in the intestinal microbiota, and bile acids are involved in this regulation. The purpose of the present study was to clarify the effect of different periods of antibiotic administration on the expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Sumio Ohtsuki

PROVIDER: PXD037296 | JPOST Repository | Wed Jul 12 00:00:00 BST 2023

REPOSITORIES: jPOST

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Effect of antibiotic-administration period on hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries.

Yagi Ryotaro R Masuda Takeshi T Ito Shingo S Ohtsuki Sumio S

Drug metabolism and pharmacokinetics 20230209

Antibiotic administration affects pharmacokinetics through changes in the intestinal microbiota, and bile acids are involved in this regulation. The purpose of the present study was to clarify the effect of different periods of antibiotic administration on the hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries. Vancomycin and polymyxin B were orally administered to mice for either 5- or 25-days. The hepatic bile acid profile ...[more]

PMID: 37119611

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