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A novel YDDX linear motif mediates docking of the IKK kinase to substrates: structural and functional insights

ABSTRACT: The inhibitor of kB kinase (IKK) is the master regulator of the nuclear factor kB (NF-kB) pathway, involved in inflammatory, immune and apoptotic responses. In the ‘canonical’ NF-kB pathway, IKK phosphorylates inhibitor of kB (IkB) proteins and this triggers ubiquitin-mediated degradation of IkB, leading to release and nuclear translocation of NF-B transcription factors. The data presented show that the IKK and IKK subunits recognize a YDDX docking site located within the disordered C-terminal region of IkBa. Our results also suggest that IKK contributes to the docking interaction with higher affinity as compared to IKK.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Juri Rappsilber

PROVIDER: PXD037534 | JPOST Repository | Thu May 09 00:00:00 BST 2024

REPOSITORIES: jPOST

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			Action	DRS
	B210905_02_Lumos_FO_CO_150_IKKbetaPlusPeptideK21_BS3_monomer_rep2.raw	Raw
	B210905_03_Lumos_FO_CO_150_IKKbetaPlusPeptideK21_BS3_monomer_rep3.raw	Raw
	B210905_05_Lumos_FO_CO_150_IKKbetaPlusPeptideK21_EDC_monomer_rep2.raw	Raw
	B220404_05_Lumos_FO_CO_120_Zanier_SDA_monomer_upper_rep1.raw	Raw
	IKKbPlusPeptide_BS3_monomer.mzid	Mzid

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