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Phosphoproteomics and global proteomic analysis of gastric cancer cell lines

ABSTRACT: proteome, pSTY proteome and pY proteome analysis was performed using 13 gastric cancer cell lines w/wo apatinib treatment.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Jun Adachi

PROVIDER: PXD037961 | JPOST Repository | Sat Nov 04 00:00:00 GMT 2023

REPOSITORIES: jPOST

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Integration of pharmacoproteomic and computational approaches reveals the cellular signal transduction pathways affected by apatinib in gastric cancer cell lines.

Nojima Yosui Y Aoki Masahiko M Re Suyong S Hirano Hidekazu H Abe Yuichi Y Narumi Ryohei R Muraoka Satoshi S Shoji Hirokazu H Honda Kazufumi K Tomonaga Takeshi T Mizuguchi Kenji K Boku Narikazu N Adachi Jun J

Computational and structural biotechnology journal 20230315

Apatinib is known to be a highly selective vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with anti-angiogenic and anti-tumor properties. In a phase III study, the objective response rate to apatinib was low. It remains unclear why the effectivity of apatinib varies among patients and what type of patients are candidates for the treatment. In this study, we investigated the anti-tumor efficacy of apatinib against 13 gastric cancer cell lines and found that it differed depending ...[more]

PMID: 37013003

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