Ontology highlight
ABSTRACT:
ORGANISM(S): Cellular Organisms
SUBMITTER: Min Luo
PROVIDER: PXD038058 | JPOST Repository | Thu Aug 31 00:00:00 BST 2023
REPOSITORIES: jPOST
Yu Lin L Xu Xin X Chua Wan-Zhen WZ Feng Hao H Ser Zheng Z Shao Kai K Shi Jian J Wang Yumei Y Li Zongli Z Sobota Radoslaw M RM Sham Lok-To LT Luo Min M
Nature communications 20231107 1
Quorum sensing (QS) is a crucial regulatory mechanism controlling bacterial signalling and holds promise for novel therapies against antimicrobial resistance. In Gram-positive bacteria, such as Streptococcus pneumoniae, ComA is a conserved efflux pump responsible for the maturation and secretion of peptide signals, including the competence-stimulating peptide (CSP), yet its structure and function remain unclear. Here, we functionally characterize ComA as an ABC transporter with high ATP affinity ...[more]