Dataset Information

Serum Proteomic Profile of Wild Stump-tailed Macaques (Macaca arctoides) Infected with Malaria Parasites in Thailand

ABSTRACT: The number of patients infected with simian malaria is increasing in many countries in Southeast Asia. The behavior of humans, monkeys, and vectors influences their interactions with each other and is the most important risk factor of zoonotic malaria infection. However, no serum proteomics study has been conducted in wild macaques. The present study was performed using a proteomics approach to explore the protein expression profile of wild stump-tailed macaques (Macaca arctoides) infected with malaria parasites.

ORGANISM(S): Cellular Organisms

SUBMITTER: Sittiruk Roytrakul

PROVIDER: PXD039047 | JPOST Repository | Fri Dec 23 00:00:00 GMT 2022

REPOSITORIES: jPOST

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			Action	DRS
	Ky1_se_1_BA5_01_11599.mzXML	Mzxml
	Ky1_se_2_BA5_01_11600.mzXML	Mzxml
	Ky1_se_3_BA5_01_11601.mzXML	Mzxml
	Ky2_se_1_BA6_01_11602.mzXML	Mzxml
	Ky2_se_2_BA6_01_11603.mzXML	Mzxml

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Project description:Description: Experimental exposure to malaria parasites can lead to development of protective immunity, providing a foothold for the development of a malaria vaccine. The goal of this study is to investigate immune transcriptional profiles associated with malaria protective immune responses induced by experimental Chemo-Prophylaxis and Sporozoites (CPS) immunization of P. falciparum-naive human volunteers. Samples for this study were obtained from a CPS-immunization study conducted in 2011 (ClinicalTrials.gov Identifier: NCT01218893), where healthy volunteers received CPS-immunization with bites from different numbers of P. falciparum-infected mosquitoes (three times 15 (n=5), 10 (n=9) or 5 (n=10)). Five control subjects received uninfected mosquito bites under chloroquine prophylaxis. Fifteen weeks after discontinuation of chloroquine prophylaxis, all volunteers were challenged by exposure to infected mosquito bites. Study Design: A maximum of 30 volunteers were divided into four groups. All volunteers received weekly chloroquine prophylaxis for a period of 13 weeks (91 days). During these 13 weeks, on days 8, 36 and 64 they were exposed to the bites of 15 mosquitoes. Group 1 (n=5, positive control) received three CPS immunizations by 15 mosquitoes infected with P. falciparum sporozoites. Group 2 (n=10) received three times 10 bites from infected mosquitoes and 5 bites from uninfected mosquitoes. Group 3 (n=10) received three times 5 bites from infected mosquitoes and 10 bites from uninfected mosquitoes. Group 4 (n=5), the negative control, received three placebo immunizations with 15 bites of uninfected mosquitoes. Fifteen weeks after discontinuation of chloroquine prophylaxis, all 30 volunteers were challenged at day 196 by the bites of 5 infectious mosquitoes and followed for 21 days. All subjects were treated with chloroquine 21 days after challenge or whenever they had a positive thick smear during that period.