Proteomics

Dataset Information

0

Interactome analysis for Kdm4B

ABSTRACT: In this project, to identify the proteins interacting with Rpd3 in the Drosophila mushroom body, the tandem affinity-purification(TAP) was performed. After in-solution digestion, the purified protein complex was analyzed by LC-MS/MS analysis using Orbitrap velos pro. PTM analysis was also performed to determine the phosphorylation site of Bur, the Kdm4B interacting protein, purified from mushroom body.

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

SUBMITTER: Yukinori Hirano 

PROVIDER: PXD039097 | JPOST Repository | Sat Aug 12 00:00:00 BST 2023

REPOSITORIES: jPOST

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Dataset's files

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Action DRS
SN170728.mgf Mgf
SN170728.raw Raw
SN170728_730.mzid Mzid
SN170729.mgf Mgf
SN170729.raw Raw
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Publications

Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention.

Takakura Mai M   Lam Yu Hong YH   Nakagawa Reiko R   Ng Man Yung MY   Hu Xinyue X   Bhargava Priyanshu P   Alia Abdalla G AG   Gu Yuzhe Y   Wang Zigao Z   Ota Takeshi T   Kimura Yoko Y   Morimoto Nao N   Osakada Fumitaka F   Lee Ah Young AY   Leung Danny D   Miyashita Tomoyuki T   Du Juan J   Okuno Hiroyuki H   Hirano Yukinori Y  

Proceedings of the National Academy of Sciences of the United States of America 20230828 36

Memory formation and forgetting unnecessary memory must be balanced for adaptive animal behavior. While cyclic AMP (cAMP) signaling via dopamine neurons induces memory formation, here we report that cyclic guanine monophosphate (cGMP) signaling via dopamine neurons launches forgetting of unconsolidated memory in <i>Drosophila</i>. Genetic screening and proteomic analyses showed that neural activation induces the complex formation of a histone H3K9 demethylase, Kdm4B, and a GMP synthetase, Bur, w  ...[more]

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