Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Hideru Obinata
PROVIDER: PXD039461 | JPOST Repository | Sun May 21 00:00:00 BST 2023
REPOSITORIES: jPOST
Zhao Xian X Kiyozuka Keisuke K Konishi Akimitsu A Kawabata-Iwakawa Reika R Minamishima Yoji Andrew YA Obinata Hideru H
The Journal of biological chemistry 20230521 7
Sphingosine 1-phosphate receptor 1 (S1PR1) is a G protein-coupled receptor essential for vascular development and postnatal vascular homeostasis. When exposed to sphingosine 1-phosphate (S1P) in the blood of ∼1 μM, S1PR1 in endothelial cells retains cell-surface localization, while lymphocyte S1PR1 shows almost complete internalization, suggesting the cell-surface retention of S1PR1 is endothelial cell specific. To identify regulating factors that function to retain S1PR1 on the endothelial cell ...[more]