Proteomics in PD1-LAG3 biology

ABSTRACT: T-cell lines with constitutively active PD-1, LAG-3 pathways or their combination were generated to drive distinct types of T-cell dysfunctionality. Global changes were cross-evaluated among T-cell lines and with the multiomic data from human cancers. Regulated genetic, metabolic and proteomic programmes of strong dysfunctionality in T cells and human cancers were identified at multiple levels.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: David Escors 

PROVIDER: PXD040408 | JPOST Repository | Tue Feb 27 00:00:00 GMT 2024

REPOSITORIES: jPOST