Proteomics

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The customized mouse serum spectral library for the DIA-MS

ABSTRACT: For a comprehensive analysis of the mouse serum proteome, a customized mouse serum spectral library was constructed and utilized for quantitative analysis using DIA-MS. Our spectral library contained information on 1,106 mouse serum proteins. Creation of the spectral library was performed using Spectronaut Pulsar X by searching against the mouse protein sequences from the UniProtKB/Swiss-Prot database with the addition of a iRT fasta database.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Yayoi Kimura 

PROVIDER: PXD041889 | JPOST Repository | Sat Mar 16 00:00:00 GMT 2024

REPOSITORIES: jPOST

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Publications

Identification of gravity-responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data-independent acquisition mass spectrometry.

Kimura Yayoi Y   Nakai Yusuke Y   Ino Yoko Y   Akiyama Tomoko T   Moriyama Kayano K   Ohira Takashi T   Saito Tomoyuki T   Inaba Yutaka Y   Kumagai Ken K   Ryo Akihide A   Hirano Hisashi H  

Proteomics 20240312 9

Physical inactivity associated with gravity unloading, such as microgravity during spaceflight and hindlimb unloading (HU), can cause various physiological changes. In this study, we attempted to identify serum proteins whose levels fluctuated in response to gravity unloading. First, we quantitatively assessed changes in the serum proteome profiles of spaceflight mice using mass spectrometry with data-independent acquisition. The serum levels of several proteins involved in the responses to estr  ...[more]

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