Proteomics

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Secretome protein enrichment with click sugars (SPECS) analysis on primary neurons cultured from embryos derived from pregnant mice treated with or without valproic acid

ABSTRACT: Autism Spectrum Disorder (ASD) is a developmental disorder characterized by impaired social communication and repetitive behaviors. In recent years, a pharmacological mouse model of ASD involving maternal administration of valproic acid (VPA) has become widely used. Newborn pups in this model show an abnormal balance between excitatory and inhibitory (E/I) signaling in neurons and exhibit ASD-like behavior. To elucidate the molecular basis of this model, we analyzed secretome of primary neurons cultured from embryos maternally treated with or without VPA.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Taisuke Tomita 

PROVIDER: PXD042099 | JPOST Repository | Sat Oct 26 00:00:00 BST 2024

REPOSITORIES: jPOST

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Dataset's files

Source:
Action DRS
171130_TOK_SPECS_inGelCBB_G1_1_25p_XL.RAW Raw
171130_TOK_SPECS_inGelCBB_G1_2_25p_XL.RAW Raw
171130_TOK_SPECS_inGelCBB_G1_3_25p_XL.RAW Raw
171130_TOK_SPECS_inGelCBB_G2_1_25p_XL.RAW Raw
171130_TOK_SPECS_inGelCBB_G2_2_25p_XL.RAW Raw
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Publications

Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons.

Yoshida Fumiaki F   Nagatomo Ryota R   Utsunomiya Shun S   Kimura Misaki M   Shun Shiyori S   Kono Rena R   Kato Yuma Y   Nao Yosuke Y   Maeda Kazuma K   Koyama Ryuta R   Ikegaya Yuji Y   Lichtenthaler Stefan F SF   Takatori Sho S   Takemoto Hiroshi H   Ogawa Koichi K   Ito Genta G   Tomita Taisuke T  

Translational psychiatry 20241023 1

Autism Spectrum Disorder (ASD) is a developmental disorder characterized by impaired social communication and repetitive behaviors. In recent years, a pharmacological mouse model of ASD involving maternal administration of valproic acid (VPA) has become widely used. Newborn pups in this model show an abnormal balance between excitatory and inhibitory (E/I) signaling in neurons and exhibit ASD-like behavior. However, the molecular basis of this model and its implications for the pathogenesis of A  ...[more]

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