Proteomics

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Microglia and brain organoids

ABSTRACT: iPSC-derived microglia export cholesterol to neuronal cells in human brain organoids and promote their maturation

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Florent Ginhoux 

PROVIDER: PXD042344 | JPOST Repository | Fri May 19 00:00:00 BST 2023

REPOSITORIES: jPOST

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iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer.

Park Dong Shin DS   Kozaki Tatsuya T   Tiwari Satish Kumar SK   Moreira Marco M   Khalilnezhad Ahad A   Torta Federico F   Olivié Nicolas N   Thiam Chung Hwee CH   Liani Oniko O   Silvin Aymeric A   Phoo Wint Wint WW   Gao Liang L   Triebl Alexander A   Tham Wai Kin WK   Gonçalves Leticia L   Kong Wan Ting WT   Raman Sethi S   Zhang Xiao Meng XM   Dunsmore Garett G   Dutertre Charles Antoine CA   Lee Salanne S   Ong Jia Min JM   Balachander Akhila A   Khalilnezhad Shabnam S   Lum Josephine J   Duan Kaibo K   Lim Ze Ming ZM   Tan Leonard L   Low Ivy I   Utami Kagistia Hana KH   Yeo Xin Yi XY   Di Tommaso Sylvaine S   Dupuy Jean-William JW   Varga Balazs B   Karadottir Ragnhildur Thora RT   Madathummal Mufeeda Changaramvally MC   Bonne Isabelle I   Malleret Benoit B   Binte Zainab Yasin ZY   Wei Da Ngan N   Tan Yingrou Y   Wong Wei Jie WJ   Zhang Jinqiu J   Chen Jinmiao J   Sobota Radoslaw M RM   Howland Shanshan W SW   Ng Lai Guan LG   Saltel Frédéric F   Castel David D   Grill Jacques J   Minard Veronique V   Albani Salvatore S   Chan Jerry K Y JKY   Thion Morgane Sonia MS   Jung Sang Yong SY   Wenk Markus R MR   Pouladi Mahmoud A MA   Pasqualini Claudia C   Angeli Veronique V   Cexus Olivier N F ONF   Ginhoux Florent F  

Nature 20231101 7986

Microglia are specialized brain-resident macrophages that arise from primitive macrophages colonizing the embryonic brain<sup>1</sup>. Microglia contribute to multiple aspects of brain development, but their precise roles in the early human brain remain poorly understood owing to limited access to relevant tissues<sup>2-6</sup>. The generation of brain organoids from human induced pluripotent stem cells recapitulates some key features of human embryonic brain development<sup>7-10</sup>. However,  ...[more]

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