Ontology highlight
ABSTRACT:
ORGANISM(S): Cellular Organisms
SUBMITTER: Masaaki Oyama
PROVIDER: PXD043453 | JPOST Repository | Tue Jun 03 00:00:00 BST 2025
REPOSITORIES: jPOST
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160722_harima_NP_02.raw | Raw | |||
160722_hata_160722_harima_NP_02.xlsx | Xlsx | |||
160725_harima_PP_02.raw | Raw | |||
160725_hata_160725_harima_PP_02.xlsx | Xlsx |
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Nature microbiology 20250603 7
Herpes simplex virus 1 (HSV-1) is the most common cause of viral encephalitis, which can be lethal or result in severe neurological defects despite antiviral therapy. The apolipoprotein B messenger-RNA editing enzyme, catalytic polypeptide-like (APOBEC) group of proteins can act as viral restriction factors. How HSV-1 evades this intrinsic immune mechanism is unclear. Here, using human carcinoma HEp-2 cells, we find that phosphorylation and therefore activation of HSV-1 uracil-DNA glycosylase co ...[more]