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Proteome analysis of secretory substances containing proteins, extracellular vehicles, and others secreted from Candida albicans cultured under normal and hypoxic conditions.

ABSTRACT: Candida albicans were cultured under normal and hypoxic conditions and collected secretome from the culture supernatant with centrifugation. The secretome contains secretory proteins, extracellular vehicles, and others.

ORGANISM(S): Candida Albicans

SUBMITTER: Krisana Asano

PROVIDER: PXD046763 | JPOST Repository | Mon Jan 29 00:00:00 GMT 2024

REPOSITORIES: jPOST

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Heat Shock Protein SSA1 Enriched in Hypoxic Secretome of Candida albicans Exerts an Immunomodulatory Effect via Regulating Macrophage Function.

Teng Wei W Subsomwong Phawinee P Narita Kouji K Nakane Akio A Asano Krisana K

Cells 20240110 2

Candida albicans is an opportunistic pathogenic yeast that can survive in both normoxic and hypoxic environments. The involvement of C. albicans secretome on host biological processes has been demonstrated. However, the immunoregulatory function of C. albicans secretome released under hypoxic condition remains unclear. This study demonstrated the differences in cytokine responses and protein profiles between secretomes prepared under normoxic and hypoxic conditions. Furtherm ...[more]

PMID: 38247818

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