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Deep proteome analysis of initial meconium from human neonates

ABSTRACT: We conducted a deep proteomic analysis of meconium in 259 newborns to establish a meconium protein profile and gain insights into the underlying causes of neonatal diseases.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Eiichiro Watanabe

PROVIDER: PXD047426 | JPOST Repository | Thu May 30 00:00:00 BST 2024

REPOSITORIES: jPOST

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			Action	DRS
	Stool-ID_001.raw	Raw
	Stool-ID_002.raw	Raw
	Stool-ID_003.raw	Raw
	Stool-ID_004.raw	Raw
	Stool-ID_005.raw	Raw

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Publications

Host-derived protein profiles of human neonatal meconium across gestational ages.

Shitara Yoshihiko Y Konno Ryo R Yoshihara Masahito M Kashima Kohei K Ito Atsushi A Mukai Takeo T Kimoto Goh G Kakiuchi Satsuki S Ishikawa Masaki M Kakihara Tomo T Nagamatsu Takeshi T Takahashi Naoto N Fujishiro Jun J Kawakami Eiryo E Ohara Osamu O Kawashima Yusuke Y Watanabe Eiichiro E

Nature communications 20240717 1

Meconium, a non-invasive biomaterial reflecting prenatal substance accumulation, could provide valuable insights into neonatal health. However, the comprehensive protein profile of meconium across gestational ages remains unclear. Here, we conducted an extensive proteomic analysis of first meconium from 259 newborns across varied gestational ages to delineate protein composition and elucidate its relevance to neonatal diseases. The first meconium samples were collected, with the majority obtaine ...[more]

PMID: 39019879

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