Proteomics

Dataset Information

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Proteome data on human MDS-L cells

ABSTRACT: Shotgun mass spectrometric analysis of WT and TOPORS KO MDS-L cells

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Masaaki Oyama 

PROVIDER: PXD048275 | JPOST Repository | Fri Mar 08 00:00:00 GMT 2024

REPOSITORIES: jPOST

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Action DRS
20220712_kaito_3.raw Raw
20220712_kaito_4.raw Raw
20220721_hata_20220712_kaito_3.xlsx Xlsx
20220721_hata_20220712_kaito_4.xlsx Xlsx
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Publications

Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization.

Kaito Satoshi S   Aoyama Kazumasa K   Oshima Motohiko M   Tsuchiya Akiho A   Miyota Makiko M   Yamashita Masayuki M   Koide Shuhei S   Nakajima-Takagi Yaeko Y   Kozuka-Hata Hiroko H   Oyama Masaaki M   Yogo Takao T   Yabushita Tomohiro T   Ito Ryoji R   Ueno Masaya M   Hirao Atsushi A   Tohyama Kaoru K   Li Chao C   Kawabata Kimihito Cojin KC   Yamaguchi Kiyoshi K   Furukawa Yoichi Y   Kosako Hidetaka H   Yoshimi Akihide A   Goyama Susumu S   Nannya Yasuhito Y   Ogawa Seishi S   Agger Karl K   Helin Kristian K   Yamazaki Satoshi S   Koseki Haruhiko H   Doki Noriko N   Harada Yuka Y   Harada Hironori H   Nishiyama Atsuya A   Nakanishi Makoto M   Iwama Atsushi A  

Nature communications 20240828 1

DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding arginine/serine-rich protein (TOPORS), which encodes a ubiquitin/SUMO E3 ligase, augments the efficacy of HMAs on myeloid leukemic cells with little effect on normal hematopoiesis, suggesting that TOPORS is involved in resistance to HMAs. HMAs are incorporated int  ...[more]

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