Dataset Information
Proteome data on human MDS-L cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Masaaki Oyama
PROVIDER: PXD048275 | JPOST Repository | Fri Mar 08 00:00:00 GMT 2024
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20220712_kaito_3.raw | Raw | |||
| 20220712_kaito_4.raw | Raw | |||
| 20220721_hata_20220712_kaito_3.xlsx | Xlsx | |||
| 20220721_hata_20220712_kaito_4.xlsx | Xlsx |
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Publications
Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization.
Nature communications 20240828 1
DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding arginine/serine-rich protein (TOPORS), which encodes a ubiquitin/SUMO E3 ligase, augments the efficacy of HMAs on myeloid leukemic cells with little effect on normal hematopoiesis, suggesting that TOPORS is involved in resistance to HMAs. HMAs are incorporated int ...[more]
