Proteomics

Dataset Information

0

MS data on DBP-interacting proteins


ABSTRACT: Shotgun proteomic analyses of Flag-DBP or Flag-Luc (control) associated proteins

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Masaaki Oyama 

PROVIDER: PXD048376 | JPOST Repository | Mon Aug 26 00:00:00 BST 2024

REPOSITORIES: jPOST

Dataset's files

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Publications


D-site binding protein, DBP, is a clock-controlled transcription factor and drives daily rhythms of physiological processes through the regulation of an array of genes harboring a DNA binding motif, D-box. DBP protein levels show a circadian oscillation with an extremely robust peak/trough ratio, but it is elusive how the temporal pattern is regulated by post-translational regulation. In this study, we show that DBP protein levels are down-regulated by the ubiquitin-proteasome pathway. Analysis  ...[more]

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