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MS data on DBP-interacting proteins

ABSTRACT: Shotgun proteomic analyses of Flag-DBP or Flag-Luc (control) associated proteins

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Masaaki Oyama

PROVIDER: PXD048376 | JPOST Repository | Mon Aug 26 00:00:00 BST 2024

REPOSITORIES: jPOST

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			Action	DRS
	131203_nunokawa_D_03.raw	Raw
	131203_nunokawa_L_02.raw	Raw
	131206_hata_131203_nunokawa_D_03_refseq_mouse7_P_Ub_CarbamidoM_PRS.xlsx	Xlsx
	131206_hata_131203_nunokawa_L_02_refseq_mouse7_P_Ub_CarbamidoM_PRS.xlsx	Xlsx

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Publications

TRAF7 determines circadian period through ubiquitination and degradation of DBP.

Masuda Shusaku S Kurabayashi Nobuhiro N Nunokawa Rina R Otobe Yuta Y Kozuka-Hata Hiroko H Oyama Masaaki M Shibata Yuri Y Inoue Jun-Ichiro JI Koebis Michinori M Aiba Atsu A Yoshitane Hikari H Fukada Yoshitaka Y

Communications biology 20241008 1

D-site binding protein, DBP, is a clock-controlled transcription factor and drives daily rhythms of physiological processes through the regulation of an array of genes harboring a DNA binding motif, D-box. DBP protein levels show a circadian oscillation with an extremely robust peak/trough ratio, but it is elusive how the temporal pattern is regulated by post-translational regulation. In this study, we show that DBP protein levels are down-regulated by the ubiquitin-proteasome pathway. Analysis ...[more]

PMID: 39379486

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