Dataset Information
A TCR blocking HLA-A*11:01-specific human monoclonal antibody
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Nicholas R.J. Gascoigne
PROVIDER: PXD053836 | JPOST Repository | Mon Jun 02 00:00:00 BST 2025
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 1H5A11_PRM_skylinefiles.zip | Other | |||
| 1H5_A11_sequences.fasta | Fasta | |||
| 2021-07-28-08-35-55_1H5_DSSO_NF_R123.zip | Other | |||
| 2021-07-28-22-18-55_1H5_SDA_NF_R123.zip | Other | |||
| 20210728_ZS_1H5A11_DSSO_NF_R1.raw | Raw |
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Publications
Occlusion of TCR binding to HLA-A*11:01 by a non-pathogenic human alloantibody.
Cellular and molecular life sciences : CMLS 20250226 1
Over the last decades, organ transplantation has made rapid progress as a curative therapy for organ failure. However, the adaptive immune system-alloreactive T cells and antibodies targeting human leukocyte antigens (HLA)-is the leading cause of graft rejection. The presence of anti-donor HLA antibodies is considered a risk factor that disqualifies a particular donor-recipient pair. However, alloantibodies are found in some long-term graft survivors, suggesting a protective blocking function of ...[more]
