Proteomics

Dataset Information

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Proteomic profiling of human corneal epithelial cells under hyperosmotic stress

ABSTRACT: This project compared the proteomic change between human corneal epithelial cells cultured under hyperosmotic and isosmotic condition. This aimed to reveal differentially expressed proteins that was associated with osmoregulation in human corneal epithelial cells.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Hang-kin KONG 

PROVIDER: PXD054330 | JPOST Repository | Wed May 14 00:00:00 BST 2025

REPOSITORIES: jPOST

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Dataset's files

Source:
Action DRS
20231227_uniprotkb_homo_sapiens_Review_ISO.fasta Fasta
20240129_160649_Orbitrap_HCEC_DED_vs_NRM.sne Other
DED1_IS_DIA.raw Raw
DED2_IS_DIA.raw Raw
DED4_IS_DIA.raw Raw
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Publications

Upregulations of SNAT2 and GLS-1 Are Key Osmoregulatory Responses of Human Corneal Epithelial Cells to Hyperosmotic Stress.

Chan Kenrick Kai-Yuen KK   Lee Alan Chun-Kit AC   Chung Shing-Yan Roy SR   Wong Man-Sau MS   Do Chi-Wai CW   Lam Thomas Chuen TC   Kong Hang-Kin HK  

Journal of proteome research 20250513 6

Dry eye syndrome (DES) affects millions of people worldwide. However, as the cellular responses of the corneal epithelium under hyperosmotic stress remain unclear, this study investigated the proteomic changes between human corneal epithelial cells (HCECs) cultured with isosmotic and hyperosmotic media. Under hyperosmotic stress, HCECs increased expressions of sodium-coupled neutral amino acid transporter (SNAT2), glutaminase (GLS-1), and a few isoforms of heat shock protein and aldo-keto reduct  ...[more]