Proteomics

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Dataset04_SUDHL4 3h 5h Gemcitabine IMPRINTS

ABSTRACT: SUDHL4 cells were treated with 24uM gemcitabine for 3h and 5h (with 5h vehicle control), collected and subjected to CETSA heating, followed by cell lysis, isolation of soluble fraction and sample preparation for MS including digestion, desalting, TMT labeling, offline fractionation and pooling.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Liang Ying Yu 

PROVIDER: PXD054901 | JPOST Repository | Thu Jun 12 00:00:00 BST 2025

REPOSITORIES: jPOST

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20211204_KK_SUD_Gem_3h5h_IMPRINTS_54_F19.raw Raw
20211204_KK_SUD_Gem_3h5h_IMPRINTS_54_F20.raw Raw
20211209_KK_SUD_Gem_3h5h_IMPRINTS_57_F10_20211214101524.raw Raw
20211209_KK_SUD_Gem_3h5h_IMPRINTS_57_F11_20211214113837.raw Raw
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Publications

Mechanisms for resistance to cytotoxic cancer drugs are dependent on dynamic changes in the biochemistry of cellular pathways, information which is hard to obtain at the systems level. Here we use a deep functional proteomics implementation of the Cellular Thermal Shift Assay to reveal a range of induced biochemical responses to gemcitabine in resistant and sensitive diffuse large B cell lymphoma cell lines. Initial responses in both, gemcitabine resistant and sensitive cells, reflect known targ  ...[more]

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