Dataset Information
Dataset11_DLBCL clinical sample 1 5h Gemcitabine ITDR
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Liang Ying Yu
PROVIDER: PXD054909 | JPOST Repository | Thu Jun 12 00:00:00 BST 2025
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20230112_YY_SLS1428_37C_FR1.raw | Raw | |||
| 20230112_YY_SLS1428_37C_FR2.raw | Raw | |||
| 20230112_YY_SLS1428_37C_FR3.raw | Raw | |||
| 20230112_YY_SLS1428_37C_FR4.raw | Raw | |||
| 20230112_YY_SLS1428_37C_FR5.raw | Raw |
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Publications
MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance.
Nature communications 20250507 1
Mechanisms for resistance to cytotoxic cancer drugs are dependent on dynamic changes in the biochemistry of cellular pathways, information which is hard to obtain at the systems level. Here we use a deep functional proteomics implementation of the Cellular Thermal Shift Assay to reveal a range of induced biochemical responses to gemcitabine in resistant and sensitive diffuse large B cell lymphoma cell lines. Initial responses in both, gemcitabine resistant and sensitive cells, reflect known targ ...[more]
