Dataset Information

Dataset08_SUDHL4 1h 8h low dose 2 Gemcitabine IMPRINTS

ABSTRACT: SUDHL4 cells were treated with 48nM gemcitabine for 1h and 8h (with 8h vehicle control), collected and subjected to CETSA heating, followed by cell lysis, isolation of soluble fraction and sample preparation for MS including digestion, desalting, TMT labeling, offline fractionation and pooling.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Liang Ying Yu

PROVIDER: PXD055016 | JPOST Repository | Thu Jun 12 00:00:00 BST 2025

REPOSITORIES: jPOST

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	202111225_KK_SUD_Gem_low_dose_47_rerun_Proteins.txt	Txt
	20211226_KK_SUD_Gem_low_dose_50-(1)_Proteins.txt	Txt
	20211226_KK_SUD_Gem_low_dose_54_F10.raw	Raw
	20211226_KK_SUD_Gem_low_dose_54_F11.raw	Raw
	20211226_KK_SUD_Gem_low_dose_54_F13.raw	Raw

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Publications

MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance.

Liang Ying Yu YY Khalid Khalidah K Le Hai Van HV Teo Hui Min Vivian HMV Raitelaitis Mindaugas M Gerault Marc-Antoine MA Lee Jane Jia Hui JJH Lyu Jiawen J Chan Allison A Jeyasekharan Anand Devaprasath AD Tam Wai Leong WL Nordlund Pär P Prabhu Nayana N

Nature communications 20250507 1

Mechanisms for resistance to cytotoxic cancer drugs are dependent on dynamic changes in the biochemistry of cellular pathways, information which is hard to obtain at the systems level. Here we use a deep functional proteomics implementation of the Cellular Thermal Shift Assay to reveal a range of induced biochemical responses to gemcitabine in resistant and sensitive diffuse large B cell lymphoma cell lines. Initial responses in both, gemcitabine resistant and sensitive cells, reflect known targ ...[more]

PMID: 40335468

Dataset Information

Dataset08_SUDHL4 1h 8h low dose 2 Gemcitabine IMPRINTS

Dataset's files

Publications

MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance.

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Weissella muntiaci strain:8H-2 | isolate:8H-2
| PRJNA516300 | ENA