Proteomics

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Analysis of exosomes released from cancer-associated glycosphingolipid-expressing cancer cells


ABSTRACT: In order to study the mechanism by which GD3/GD2-containing EVs released from gliomas in the actions toward target cells, we performed proteome analysis of EVs with/without GD3/GD2.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Koichi Furukawa, Keiko Furukawa 

PROVIDER: PXD056795 | JPOST Repository | Wed Oct 15 00:00:00 BST 2025

REPOSITORIES: jPOST

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Publications

Action Mechanisms of Exosomes Derived from GD3/GD2-Positive Glioma Cells in the Regulation of Phenotypes and Intracellular Signaling: Roles of Integrins.

Hasnat Mohammad Abul MA   Ohmi Yuhsuke Y   Yesmin Farhana F   Kaneko Kei K   Kambe Mariko M   Kitaura Yoko Y   Ito Takako T   Imao Yuka Y   Kano Keiko K   Mishiro-Sato Emi E   Koyanagi Hiroka H   Kawamoto Yoshiyuki Y   Bhuiyan Robiul Hasan RH   Ohkawa Yuki Y   Tajima Orie O   Furukawa Koichi K   Furukawa Keiko K  

International journal of molecular sciences 20241127 23


Extracellular vesicles (EVs) play important roles in intercellular communication in various biological events. In particular, EVs released from cancer cells have attracted special attention. Although it has been reported that cancer-associated glycosphingolipids play important roles in the enhancement of malignant properties of cancer cells, the presence, behavior, and roles of glycosphingolipids in EVs have not been elucidated. Recently, we reported crucial roles of EVs expressing gangliosides,  ...[more]

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