Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human) Escherichia Coli
SUBMITTER: Duyoung Min
PROVIDER: PXD056895 | JPOST Repository | Wed Nov 27 00:00:00 GMT 2024
REPOSITORIES: jPOST
Kim Seoyoon S Kim Eojin E Park Mingyu M Kim Seong Ho SH Kim Byung-Gyu BG Na Seungjin S Sadongo Victor W VW Wijesinghe W C Bhashini WCB Eom Yu-Gon YG Yoon Gwangsu G Jeong Hannah H Hwang Eunhye E Lee Chaiheon C Myung Kyungjae K Kim Chae Un CU Choi Jeong-Mo JM Min Seung Kyu SK Kwon Tae-Hyuk TH Min Duyoung D
Nature communications 20241230 1
Oxidative modifications can disrupt protein folds and functions, and are strongly associated with human aging and diseases. Conventional oxidation pathways typically involve the free diffusion of reactive oxygen species (ROS), which primarily attack the protein surface. Yet, it remains unclear whether and how internal protein folds capable of trapping oxygen (O<sub>2</sub>) contribute to oxidative damage. Here, we report a hidden pathway of protein damage, which we refer to as O<sub>2</sub>-conf ...[more]