Intact-cell thermal PISA-MS target-engagement profiling of M5717 in Plasmodium falciparum

ABSTRACT: Here we demonstrate eEF1-alpha and eEF2 stabilisation by M5717 in the intact-cell P. falciparum-infected red blood cells, using thermal Proteome Integral Solubility Alteration (Thermal PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).

ORGANISM(S): Plasmodium (plasmodium)

SUBMITTER: Jerzy Dziekan, Alan Cowman 

PROVIDER: PXD059612 | JPOST Repository | Tue Feb 17 00:00:00 GMT 2026

REPOSITORIES: jPOST