Dataset Information

Pfs230 and Pfs48/45 complex SDA XL-MS

ABSTRACT: Asexual P. falciparum parasite cultures were maintained, gametocytes harvested and pellets lysed prior to chromatography procedures including size exclusion. Chemical cross-linking MS (XL-MS) analysis using SDA and UV exposure was performed followed by SDS-PAGE, gel bands excised and subjected to trypsin digestion and MS analysis.

ORGANISM(S): Plasmodium (plasmodium)

SUBMITTER: Wai-Hong Tham

PROVIDER: PXD060341 | JPOST Repository | Tue Jan 27 00:00:00 GMT 2026

REPOSITORIES: jPOST

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Publications

Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex.

Dietrich Melanie H MH Chmielewski Jill J Chan Li-Jin LJ Tan Li Lynn LL Adair Amy A Lyons Frankie M T FMT Gabriela Mikha M Lopaticki Sash S Dite Toby A TA Dagley Laura F LF Pazzagli Lucia L Gupta Priya P Kamil Mohd M Vaughan Ashley M AM Rojrung Rattanaporn R Abraham Anju A Mazhari Ramin R Longley Rhea J RJ Zeglinski Kathleen K Gouil Quentin Q Mueller Ivo I Fabb Stewart A SA Shandre-Mugan Rekha R Pouton Colin W CW Glukhova Alisa A Shakeel Shabih S Tham Wai-Hong WH

Science (New York, N.Y.) 20250911 6765

Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and Pfs48/45 proteins are critical for male fertility and transmission of the malaria parasite. They form a core fertilization complex, but it is unknown how they interact. We determined a cryo-electron microscopy structure of the endogenous Pfs230-Pfs48/45 complex showing that Pfs48/45 interact ...[more]

PMID: 40743371

			Action	DRS
	P4536.fasta	Fasta
	P4536_01.mgf	Mgf
	P4536_01.raw	Raw
	P4536_02.mgf	Mgf
	P4536_02.raw	Raw

Dataset Information

Pfs230 and Pfs48/45 complex SDA XL-MS

Dataset's files

Publications

Cryo-EM structure of endogenous <i>Plasmodium falciparum</i> Pfs230 and Pfs48/45 fertilization complex.

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