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Global proteomics and metabolomic data of PROTAC in cancer cells

ABSTRACT: Global proteomics and metabolomic data of PROTAC in cancer cells are deposited here.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Hong-yu Li

PROVIDER: PXD061773 | JPOST Repository | Thu Mar 13 00:00:00 GMT 2025

REPOSITORIES: jPOST

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			Action	DRS
	Global_proteomics_033949_QinZ_20241126_02_DIA.sne	Other
	Global_proteomics_QinZ_20241126_02_DIA_raw.zip	Other
	Metabolomic_assay_raw_data_%5Bupload%5D.zip	Other
	SUPPOR~1.XLS	Xls
	Table_S4_Metabolomic_analysis_of_compounds_results.xlsx	Xlsx

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Global proteomics and metabolomic data of PROTAC in cancer cells

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Project description:Although multiple gene and protein expression have been extensively profiled in human pulmonary arterial hypertension (PAH), the mechanism for the development and progression of pulmonary hypertension remains elusive. Analysis of the global metabolomic heterogeneity within the pulmonary vascular system leads to a better understanding of disease progression. Using a combination of high-throughput liquid-and-gas-chromatography-based mass spectrometry, we showed unbiased metabolomic profiles of disrupted glycolysis, increased TCA cycle, and fatty acid metabolites with altered oxidation pathways in the severe human PAH lung. The results suggest that PAH has specific metabolic pathways contributing to increased ATP synthesis for the vascular remodeling process in severe pulmonary hypertension. These identified metabolites may serve as potential biomarkers for the diagnosis of severe PAH. By profiling metabolomic alterations of the PAH lung, we reveal new pathogenic mechanisms of PAH in its later stage, which may differ from the earlier stage of PAH, opening an avenue of exploration for therapeutics that target metabolic pathway alterations in the progression of PAH. Global profiles were determined in human lung tissue and compared across 11 normal and 12 severe pulmonary arterial hypertension patients. Using a combination of microarray and high-throughput liquid-and-gas-chromatography-based mass spectrometry, we showed unbiased metabolomic profiles of disrupted glycolysis, increased TCA cycle, and fatty acid metabolites with altered oxidation pathways in the severe human PAH lung.

2014-11-14 | E-GEOD-53408 | biostudies-arrayexpress