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In vitro anti-mycobacterial effect of pH-responsive niosome loaded with lactoferricin via modulating inflammatory response-associated proteins in alveolar macrophage

ABSTRACT: Conventional antitubercular drugs for tuberculosis (TB) encounter a serious challenge related to the adverse outcomes caused by extended treatment duration and drug resistance. Thus, developing an innovative platform with effective anti-TB activity would offer more advantages.

ORGANISM(S): Cellular Organisms

SUBMITTER: Khajornsak Tragoolpua

PROVIDER: PXD061866 | JPOST Repository | Sun Mar 15 00:00:00 GMT 2026

REPOSITORIES: jPOST

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			Action	DRS
	Infected_Cell%20Empty_BC3_01_40782.mgf	Mgf
	Infected_Cell%20Empty_BC3_01_40782.mzXML	Mzxml
	Infected_Cell%20Empty_BC3_01_40783.mgf	Mgf
	Infected_Cell%20Empty_BC3_01_40783.mzXML	Mzxml
	Infected_Cell%20Empty_BC3_01_40784.mzXML	Mzxml

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Project description:Short sleep duration is associated with adverse metabolic, cardiovascular, and inflammatory effects. Co-twin study methodologies account for familial (e.g., genetics and shared environmental) confounding, allowing assessment of subtle environmental effects, such as the effect of short habitual sleep duration on gene expression. Therefore, we sought to investigate gene expression in monozygotic twins discordant for actigraphically phenotyped habitual sleep duration. Eleven healthy monozygotic twin pairs (82% female; mean age 42.7 years; SD=18.1), selected based on subjective sleep duration discordance, were objectively phenotyped for habitual sleep duration with two-weeks of wrist actigraphy. Peripheral blood leukocyte (PBL) RNA from fasting blood samples was obtained on the final day of actigraphic measurement and hybridized to Illumina humanHT-12 microarrays. Differential gene expression was determined between paired samples and mapped to functional categories using Gene Ontology. Next, a more comprehensive gene set enrichment analysis was performed based on the entire PBL transcriptome. The mean 24 hour sleep duration of the total sample was 439.2 minutes (SD=46.8 minutes; range 325.4 to 521.6 minutes). Mean within-pair sleep duration difference per 24 hours was 64.4 minutes (SD=21.2; range 45.9 to 114.6 minutes). The twin cohort displayed distinctive pathway enrichment based on sleep duration differences. Short sleep was associated with up-regulation of genes involved in transcription, ribosome, translation and oxidative phosphorylation. Unexpectedly, genes down-regulated in short sleep twins were highly enriched in immuno-inflammatory pathways such interleukin signaling and leukocyte activation, as well as developmental programs, coagulation cascade, and cell adhesion. Objectively assessed habitual sleep duration in monozygotic twin pairs appears to be associated with distinct patterns of differential gene expression and pathway enrichment. By accounting for familial confounding and measuring real life sleep duration, our study shows the transcriptomic effects of short sleep on dysregulated immune response and provides a potential link between sleep deprivation and adverse metabolic, cardiovascular and inflammatory outcomes.

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In vitro anti-mycobacterial effect of pH-responsive niosome loaded with lactoferricin via modulating inflammatory response-associated proteins in alveolar macrophage

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