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Shrimp Oil alleviates white matter lesions and improves cognitive deficits by attenuating neuroinflammation in chronic cerebral hypoperfusion rat model

ABSTRACT: Vascular dementia (VaD), resulting from chronic cerebral hypoperfusion (CCH), is the second among the age-related problems in an aging population worldwide. Neuroinflammation is increasing linked to the pathological process of VaD. Shrimp oil is a processing shrimp by-product containing abundance of astaxanthin and lipids including n-3 polyunsaturated fatty acids (PUFAs).

ORGANISM(S): Cellular Organisms

SUBMITTER: Jiraporn Tocharus

PROVIDER: PXD063656 | JPOST Repository | Tue May 06 00:00:00 BST 2025

REPOSITORIES: jPOST

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			Action	DRS
	Brain%200.25A1_BD2_01_35679.mzXML	Mzxml
	Brain%200.25A1_BD2_01_35680.mzXML	Mzxml
	Brain%200.25A1_BD2_01_35681.mzXML	Mzxml
	Brain%200.25A2_BD3_01_35682.mzXML	Mzxml
	Brain%200.25A2_BD3_01_35683.mzXML	Mzxml

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Project description:ObjectiveCurrently, most models of vascular cognitive impairment are established by occluding the carotid arteries uni- or bilaterally to reduce the cerebral blood flow mimicking chronic cerebral hypoxia. Due to the sudden blood flow interruption, a gradual narrowing of the carotid artery cannot be completely imitated. This paper aims to establish a bilateral carotid stenosis model with mild cognitive dysfunction and mild white matter changes to simulate patients with vascular predementia.MethodsAged Wistar rats (18 months old) underwent either bilateral common carotid artery stenosis (BCAS) or occlusion (BCAO) surgery or a sham operation (control group). The cerebral blood flow in the frontal cortex was measured using Doppler flowmetry. Thirty days after surgery, cognitive function impairments were determined with the Morris water maze; cerebral magnetic resonance imaging was performed to detect changes in fractional anisotropy to assess white matter injuries, and histological studies were performed.ResultsThe aged rats in the BCAS group showed a more gradual cerebral blood flow reduction and a lower mortality rate (11%) compared to rats in the BCAO group. The water maze test revealed a more marginal impairment affecting spatial learning and memory in rats with BCAS than in rats with BCAO. Diffusion tensor imaging detected white matter injuries in the hippocampus and cerebral cortex of BCAS rats. Particularly, a small portion of nerve fibers of the lateral somatosensory cortex was significantly different between rats of the BCAO and BCAS groups. In the BCAS group, the microscopic structure of the hippocampal CA1 region changed slightly after 30 days and sustained a slight mitochondrial crista crack. Fluorescence staining indicated that the number of GFAP-positive cells was increased in rat brains of the BCAS group, and this phenomenon was even more pronounced in the BCAO group. The hnRNPA2/B1 and GABAAR-α1 expression levels were significantly decreased in the hippocampus of rats with BCAS compared to those of controls.ConclusionSevere bilateral carotid stenosis induced mild cognitive dysfunction and slight structural changes in the brains of aged rats. Thus, a chronic cerebral hypoperfusion model was successfully established.

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Shrimp Oil alleviates white matter lesions and improves cognitive deficits by attenuating neuroinflammation in chronic cerebral hypoperfusion rat model

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