Proteomics

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Strategies for Acid and Amine Cross-linking and Labeling for Protein Structural Characterization Using Mass Spectrometry


ABSTRACT: Raw data from the manuscript "Strategies for Acid and Amine Cross-linking and Labeling for Protein Structural Characterization Using Mass Spectrometry" in Analytical Chemistry 2025 vol 97 issue 15

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Ian K Webb 

PROVIDER: PXD063980 | JPOST Repository | Thu May 15 00:00:00 BST 2025

REPOSITORIES: jPOST

Dataset's files

Source:
Action DRS
2-18-2024_7ASYN_ZLXL_ECD.raw Raw
2-18-2024_8ASYN_ZLXL_ECD.raw Raw
2-18-2024_9ASYN_ZLXL_ECD.raw Raw
2-26-2024_7ASYN_ZLXL_ECD.raw Raw
2-27-2024_8ASYN_ZLXL_ECD.raw Raw
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Publications

Strategies for Acid and Amine Cross-linking and Labeling for Protein Structural Characterization Using Mass Spectrometry.

Dollar Ashlyn N AN   Webb Ian K IK  

Analytical chemistry 20250410 15


Cross-linking and covalent labeling are common tools for protein structural elucidation by mass spectrometry. However, despite the importance of electrostatic interactions in proteins, there are not many tools for probing both acids and amines. Therefore, we introduce novel solution-phase amine-to-acid cross-linkers and single reagent amine and acid covalent labels utilizing carbodiimide chemistry. Cross-linking and labeling sites were determined using top-down and enzymatic digestion approaches  ...[more]

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