Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Stage-Specific Phosphoproteomic Profiling Reveals Key Signaling and Metabolic Drivers in Equine Melanocytic Neoplasm Progression

ABSTRACT: Equine Melanocytic Neoplasms (EMN) are aggressive tumors with high metastatic potential and limited therapeutic options, yet their molecular pathogenesis remains poorly understood. This study presents the first comprehensive phosphoproteomic profiling of EMN tissue biopsies, aiming to identify stage-specific alterations in signaling and metabolic pathways that drive disease progression.

ORGANISM(S): Cellular Organisms

SUBMITTER: Parichart Tesena

PROVIDER: PXD065534 | JPOST Repository | Fri Jun 26 00:00:00 BST 2026

REPOSITORIES: jPOST

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	EM1_1.mzXML	Mzxml
	EM1_2.mzXML	Mzxml
	EM1_3.mzXML	Mzxml
	EM2_1.mzXML	Mzxml
	EM2_2.mzXML	Mzxml

Items per page:

1 - 5 of 20

Similar Datasets

Proteomic profiling uncovers potential proteins for biomonitoring equine melanocytic neoplasm

Project description:The proteomic analysis of serum sample was performed to identify and quantify the expression of proteins between normal and Equine melanocytic neoplasm (EMN) gray horse.

2021-05-05 | PXD025793 | JPOST Repository

Phosphorylation of SNW 1 Protein associated with Equine Melanocytic Neoplasm identified in Serum and Feces

Project description:Equine melanocytic neoplasm (EMN) represents a form of skin tumor observed predominantly in grey horses aged over 15 years. Despite its prevalence, current therapeutic and preventive strategies for EMN have been subject to limited investigation. This study endeavors to shed light on potential phosphoproteins present in equine serum and fecal samples, potentially linked to EMN, with a specific focus on functional interactions in EMN pathogenesis.

2025-05-10 | PXD052157 | JPOST Repository

Identification of Wnt protein involvement in equine melanocytic neoplasm of grey horses: Insights from proteomic analysis and immunohistochemistry

Project description:Equine melanocytic neoplasm (EMN) is a skin tumor affecting grey horses over 15 years of age, with limitations to current therapeutic and preventative strategies. This study aims to identify potential protein expressions and biomarkers for EMN through proteomic and immunohistochemical analysis of tissue biopsy samples from normal grey horses and those at early and severe stages of EMN.

2025-02-25 | PXD056520 | JPOST Repository

Fecal Proteomic and Functional Analysis of Equine Melanocyt-ic Neoplasm in the Grey Coat Color

Project description:Equine melanocytic neoplasm (EMN) is the common disease in the older grey horse. The purpose of this study was to examine the potential protein throughout EMN stages from fecal proteomic outlining using functional analysis. Fecal samples were collected from rectum of 25 grey horses divided into three groups; normal group without EMN (n=10), mild EMN (n=6) and severe EMN (n=9). From the results, some potential proteins can be used as candidate biomarkers for the monitoring of early EMN, development of EMN, further prevention and treatment.

2021-12-17 | PXD030474 | JPOST Repository

Equine Laminitis vs Control.

Project description:Equine lameller tissues were collected to compare normal vs laminitis generated differences in transcriptom level. Keywords: Laminitis, Equine, Diseased foot

2008-03-22 | GSE7360 | GEO

In vitro effects of equine autologous conditioned serum and autologous equine serum on inflamed chondrocyte pellets

Project description:The aim of the study was to investigate the effects of autologous equine serum (AES) incubated for 24 h and autologous conditioned serum (ACS) on inflamed equine chondrocyte pellets in vitro.

2023-04-19 | GSE152253 | GEO

Transcription profiling of horse equine Laminitis samples vs Control.

Project description:Equine lameller tissues were collected to compare normal vs laminitis generated differences in transcriptom level. Experiment Overall Design: Three Laminitis generated vs three normal Equine hoof tissues were subjected to comparison analysis in transcriptom level by using the Affymetrix Bovine GeneChip. Experiment Overall Design: The reasons for Bovine chip were; 1) Genetic similarity to Equine. Experiment Overall Design: 2) More transcriptom was search at that Affymetrix platform comparing the Equine GeneChip at the time of the study.

2008-11-06 | E-GEOD-7360 | biostudies-arrayexpress

Gene expression profiling in equine polysaccharide storage myopathy

2009-04-08 | GSE15572 | GEO

Gene expression profiling in equine polysaccharide storage myopathy

Project description:Standardized muscular biopsies of the dorsal compartment of the gluteus medius muscle were performed in 7 horses suffering from equine polysaccharide storage myopathy (PSSM) and 6 sound Norman Cob horses . Gene expression analysis was performed using an equine oligonucleotide microarray which included 384 equine gene probes of the nuclear genome and all the mitochondrial genes. All the samples of PSSM muscles were hybridized against the reference control muscles. This reference was made by pooling together all the mRNA extracted after in vitro transcription from the 6 control muscles of the sound horses. Briefly, the hybridization protocol was adapted from Le Brigand et al. (2006). An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes. Nucleic Acids Res. 2006 Jul 19;34(12).

2009-04-08 | E-GEOD-15572 | biostudies-arrayexpress

Distinct molecular profiles underpin mild to moderate equine asthma cytological profiles

Project description:This project used a state-of-the-art, multi-omics approach to improve our understanding of the aetiopathogenesis of a highly prevalent, performance-limiting disorder of racehorses; mild to moderate equine asthma (MMEA). This advanced knowledge is a prerequisite to improving prophylactic, management and therapeutic options for this condition. Although a number of risk factors for MMEA have been identified, incomplete understanding of the precise aetiopathogenesis of this syndrome means that options for intervention are currently limited. This study aimed to apply a multi-omic approach, reveal key inflammatory pathways involved in inflammatory cell recruitment to the lower airways and highlight pathways specific to different MMEA inflammatory cell profiles (MMEA endotypes). Thus, we compared BALF cell gene and protein expression data from horses with normal bronchoalveolar lavage fluid (BALF) cytology (n = 8) with those isolated from horses with neutrophilic (n = 4), mastocytic (n = 8), mixed neutrophilic/mastocytic (n=4) and mixed eosinophilic/mastocytic (n=3) inflammation. Analyses on transcriptomic and proteomic data derived from BALF cells from horses with neutrophilic cytology showed enrichment in classical inflammatory pathways, while horses with mastocytic cytology showed enrichment in pathways involved in hypersensitivity reactions related to non-classical inflammation that could mimic a Th2 immune response. The mixed eosinophilic/mastocytic group also presented with a non-classical inflammatory profile while, the mixed neutrophilic/mastocytic group revealed profiles consistent with both neutrophilic inflammation and hypersensitivity. Our adopted multi-omics approach (both gene and protein expression) has enabled a more holistic assessment of the immunological status of the lower airways associated with the different cytological profiles of equine asthma.

2024-12-05 | GSE277308 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data