Proteomics

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LC-MS/MS analysis of pancreatic proteins from WT and Mettl18 KO mice

ABSTRACT: Label-free quantification of pancreatic proteins from WT and Mettl18 KO mice.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Yoichi Shinkai 

PROVIDER: PXD065601 | JPOST Repository | Wed Feb 18 00:00:00 GMT 2026

REPOSITORIES: jPOST

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Dataset's files

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Action DRS
230815_QE2_132_Shimazu_01_WT1.raw Raw
230815_QE2_132_Shimazu_02_WT2.raw Raw
230815_QE2_132_Shimazu_03_WT3.raw Raw
230815_QE2_132_Shimazu_04_KO1.raw Raw
230815_QE2_132_Shimazu_05_KO2.raw Raw
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Publications

METTL18 ensures pancreatic function by maintaining proper translation and proteostasis.

Shimazu Tadahiro T   Gowa Megumi M   Kataoka Ayane A   Suzuki Takehiro T   Tomuro Kotaro K   Shichino Yuichi Y   Dohmae Naoshi N   Iwasaki Shintaro S   Shinkai Yoichi Y  

Molecular metabolism 20260217

Methyltransferases fine-tune various biomolecules by site-specific methylation. METTL18, an N3-position-specific histidine methyltransferase, modifies H245 of the ribosomal protein RPL3 (uL3), thereby regulating translation dynamics and proteostasis. However, the physiological role of this enzyme in vivo remains to be elucidated. Here, we show that METTL18 is essential for pancreatic function by regulating translation and suppressing protein aggregation. Mettl18 knockout (KO) mice exhibited part  ...[more]

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