Intranasal administration of balenine alleviates neurodegeneration and inflammation in a mouse model of Parkinson’s disease

ABSTRACT: Imidazole dipeptides (IDPs) have physiological properties, including antioxidant, pH-buffering, and metal ion chelating activities. Carnosine, an IDP, shows promise for treating neurodegenerative diseases, including Parkinson’s disease (PD). However, carnosine-degrading enzymes limit its bioavailability. To overcome this, we focused on balenine, a carnosine analog featuring a methylated imidazole that is resistant to degradation enzymes. In this study, we established a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride (MPTP)-induced PD mouse model and administered balenine via nasal drops to target the brain via the olfactory epithelium. The MPTP-induced PD mouse model was evaluated through various behavioral tests and biochemical analyses. Proteomic analysis was used to explore the mechanism underlying the neuroprotective effects of balenine.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Taku Ozaki 

PROVIDER: PXD065872 | JPOST Repository | Fri Jun 05 00:00:00 GMT+01:00 2026

REPOSITORIES: jPOST