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Platelet proteomics on less than a drop of previously frozen, non-citrate plasma

ABSTRACT: Method development for high-throughput, sample-sparing platelet proteomics from previously frozen plasma and application of this method to a COVID-19 cohort

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Hanno Steen

PROVIDER: PXD069164 | JPOST Repository | Tue May 05 00:00:00 BST 2026

REPOSITORIES: jPOST

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			Action	DRS
	Plate2_C10_PPP_60SPD_S2-C10_1_22440.d.zip	Other
	Plate2_C11_PPP_60SPD_S2-C11_1_22441.d.zip	Other
	Plate2_C11_platelets_60SPD_S4-C11_1_22533.d.zip	Other
	Plate2_C11_platelets_60SPD_S4-C11_1_22697.d.zip	Other
	Plate2_C12_PPP_60SPD_S2-C12_1_22442.d.zip	Other

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Platelet proteomics on less than a drop of previously frozen, non-citrate plasma.

Tabang Dylan Nicholas DN Korff Kathrin K Brannon Kaitlin K Tilburg Julia J Mandal Komal K Viodé Arthur A van Zalm Patrick W PW Ravishankar Arjun A Cheong Jin-Gyu JG Schott Oliver O Arnaout Ramy R Josefowicz Steven Z SZ Italiano Joseph E JE Steen Hanno H Smolen Kinga K KK

Molecular omics 20260501 3

Platelets are blood components not regularly analysed with proteomics due to the conventional wisdom that plasma for platelet research must be citrate-treated and freshly sampled to minimize artifactual changes. Information from platelets is complementary to plasma, specifically regarding immunophenotyping of patients with challenged immune systems due to infection or inflammation. We sought to develop a sample-sparing, high-throughput-compatible platelet proteomics workflow applicable to previo ...[more]

PMID: 42059667

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