Dataset Information
Identification of PMV as the target of WEHI-601
Ontology highlight
ABSTRACT:
ORGANISM(S): Plasmodium (plasmodium)
SUBMITTER: Jerzy Michal Dziekan, Alan Cowman
PROVIDER: PXD069420 | JPOST Repository | Sat Feb 14 00:00:00 GMT 2026
REPOSITORIES: jPOST
Dataset's files
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Publications
Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in <i>Plasmodium falciparum</i> Parasites.
ACS infectious diseases 20251202 12
Plasmepsin V (PMV), an essential aspartyl protease, plays a critical role during the asexual blood stage of infection of <i>Plasmodium</i> by enabling the export of parasite proteins into the host red blood cell. This export is vital for parasite survival and pathogenesis, making PMV an attractive target for antimalarial drug development. Peptidomimetic inhibitors designed to mimic the natural substrate of PMV have demonstrated potent parasite-killing activity by blocking protein export. While t ...[more]
