Dataset Information
DRT1 FLAG Pulldown Raw Data from Exploris 480
Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia Coli
SUBMITTER: Robert Trachman
PROVIDER: PXD070039 | JPOST Repository | Fri Jul 10 00:00:00 BST 2026
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20250527-S01_01.raw | Raw | |||
| 20250527-S02_01.raw | Raw | |||
| 20250527-S03_01.raw | Raw | |||
| 20250527-S04_01.raw | Raw | |||
| 20250527-S05_01.raw | Raw |
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Publications
Semirandom DNA adducts regulate a filamentous defense-associated reverse transcriptase.
Nature structural & molecular biology 20260610 6
Retrons and several defense-associated reverse transcriptases (DRTs) synthesize non-genomic DNA for bacteriophage immunity. In some instances, this non-genomic DNA is of undefined, semirandom sequence. How undefined DNA sequences impart antiphage defense is not known. Herewe report the cryo-EM structure and functional characterization of the DRT1 antiphage defense system. We show that DRT1 performs template-free, protein-primed DNA synthesis to generate semirandom DNA adducts. DNA synthesis acti ...[more]
